Chlorosulfonic acid → 1-(Trifluoroacetyl)-2,3-dihydro-1H-indole-5-sulfonyl chloride
反応式
[F:1][C:2]([F:15])([F:14])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)=[O:4].[Cl:16][S:17](O)(=[O:19])=[O:18]>>[F:15][C:2]([F:1])([F:14])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([S:17]([Cl:16])(=[O:19])=[O:18])=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)=[O:4]参加物
3
実験手順
2,2,2-trifluoro-1-(indolin-1-yl)ethanone (5 g, 16 mmol) was added to neat chlorosulfonic acid at 0° C. and then the solution was allowed to warm to rt and stirred for an additional 2 hrs. Reaction mixture was slowly added to ice chips and stirred for 10 min then filtered off 4.2 g of the title compound as a dark red colored solid.
後処理
- customReaction mixture
- additionwas slowly added to ice chips
- stirringstirred for 10 min
- filtrationthen filtered off 4.2 g of the title compound as a dark red colored solid
出典と根拠
- ORDレコード
- ord-6905320e0f504b3b9d75917496af3bf9
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461134B2
反応ノート
読み込み中…