Nitric Acid → N-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine
反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][N:4]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>O>[CH3:1][NH:2][C:3]1[C:8]([N+:18]([O-:20])=[O:19])=[CH:7][C:6]([C:9]([F:12])([F:10])[F:11])=[CH:5][N:4]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
Into a mixture of 17.3 g of N-methyl(5-trifluoromethylpyridin-2-yl)-amine and 100 ml of sulfuric acid was dropped 12.3 g of nitric acid, then, the mixture was stirred for 2 hours while heating at 80° C. After cooling down to room temperature, water was poured into the reaction mixture, and the deposited precipitate was filtrated, then, washed with water, then, dried under reduced pressure to obtain 18.8 g of N-methyl(3-nitro-5-trifluoromethylpyridin-2-yl)-amine.
後処理
- temperatureAfter cooling down to room temperature
- filtrationthe deposited precipitate was filtrated
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-5847bb67d5674dbbbe148653720d92df
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461181B2
反応ノート
読み込み中…