Thionyl Chloride → HCID 86659460、化合物

HRID 1256633

反応式

HRID 1256633 の反応式
[ClH:1].[N:2]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11](O)=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:19])=O>O1CCCC1>[ClH:19].[N:2]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11]([Cl:1])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 185258743-[(Pyrrolidin-1-yl)methyl]benzoic acid hydrochloride

生成物 1

HCID 86659460HCID 86659460、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A suspension of 3-pyrrolidin-1-ylmethyl-benzoic acid hydrochloride (850 mg, 3.5 mmol) in dry tetrahydrofuran was treated with 2.55 mL of thionyl chloride (35 mmol, 10 eq) and stirred at room temperature for 2 hours. The solution thus obtained was then evaporated to dryness, the residue suspended in dry toluene, evaporated to dryness and dried under vacuum affording the title compound as pale brown solid (quantitative).

後処理

  1. customThe solution thus obtained
  2. customwas then evaporated to dryness
  3. customevaporated to dryness
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-f80cf0c6d3fd4e84802ff117c8cf085f
出典データセット
uspto-grants-2013_06
特許番号
US08461193B2

関連ノート

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