ethyl 1-(2-tert-butoxy-2-oxoethyl)-1H-pyrazole-4-carboxylate → [4-(ethoxycarbonyl)-1H-pyrazol-1-yl]acetic acid
反応式
C([O:5][C:6](=[O:18])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:10]=[N:9]1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:16]([O:15][C:13]([C:11]1[CH:10]=[N:9][N:8]([CH2:7][C:6]([OH:18])=[O:5])[CH:12]=1)=[O:14])[CH3:17]参加物
3
実験手順
The compound (17.5 g) obtained in Example 115a was added to trifluoroacetic acid (280 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was washed with hexane, and dried to give the title compound (15.0 g) as a colorless solid.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- washthe residue was washed with hexane
- customdried
出典と根拠
- ORDレコード
- ord-09e4e0fb3f704497bab09c9b872ea197
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461348B2
反応ノート
読み込み中…