Oxalyl chloride → Methyl 4-(2-chloro-2-oxoethyl)benzoate

HRID 1257474ノート

反応式

HRID 1257474 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)=[O:4].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[Cl:18][C:12](=[O:14])[CH2:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 107978792-(4-(Methoxycarbonyl)phenyl)acetic acid

生成物 1

HCID 19746402Methyl 4-(2-chloro-2-oxoethyl)benzoate

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of the compound (3.0 g) obtained in Example 206a in dichloromethane (50 mL) was cooled in an ice bath, and oxalyl chloride (3.93 g) and N,N-dimethylformamide (2 drops) were added. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure to give the title compound.

後処理

  1. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-f6db7af0968d4d169df79cf7eee4e942
出典データセット
uspto-grants-2013_06
特許番号
US08461348B2

反応ノート

読み込み中…