Methyl 1-benzyl-2,4-dioxo-3-piperidinecarboxylate → 1-Benzylpiperidine-2,4-dione
反応式
COC([CH:5]1[C:10](=[O:11])[CH2:9][CH2:8][N:7]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]1=[O:19])=O>CC#N.O>[CH2:12]([N:7]1[CH2:8][CH2:9][C:10](=[O:11])[CH2:5][C:6]1=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1参加物
4
実験手順
A solution of 1-benzyl-2,4-dioxo-piperidine-3-carboxylic acid methyl ester (2.09 g, 8.0 mmol) in MeCN (250 mL) and water (20 mL) was heated at reflux for 76 hours. The cooled reaction mixture was concentrated under vacuum to afford 1.60 g (98%) of 1-benzyl-piperidine-2,4-dione as a yellow oil. 1H NMR (400 MHz, CDCl3) δ: 7.36-7.24 (m, 5H), 4.69 (s, 2H), 3.48 (t, 2H), 3.43 (s, 2H), 2.54 (t, 2H).
後処理
- temperatureat reflux for 76 hours
- customThe cooled reaction mixture
- concentrationwas concentrated under vacuum
出典と根拠
- ORDレコード
- ord-deb45b2c28a142a6a082194aea0f5a69
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461328B2
反応ノート
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