Dimethylformamide → 3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride

HRID 1257987ノート

反応式

HRID 1257987 の反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([CH3:19])=[C:8]([CH:12]=[CH:13][C:14]=1[S:15]([CH3:18])(=[O:17])=[O:16])[C:9](O)=[O:10].S(Cl)([Cl:22])=O.CN(C=O)C>C1(C)C=CC=CC=1>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([CH3:19])=[C:8]([CH:12]=[CH:13][C:14]=1[S:15]([CH3:18])(=[O:17])=[O:16])[C:9]([Cl:22])=[O:10]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 667565243-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid

生成物 1

HCID 866548323-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
100 °C

実験手順

3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid (100 g) and toluene (300 mL) were mixed, and thionyl chloride (47.5 g) and DMF (2.5 g) were added, followed by heating and stirring at 100° C. for 2 hours. After completion of the reaction, 180 mL of toluene was distilled off under reduced pressure to obtain a solution of 3-(2-methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoyl chloride.

後処理

  1. temperatureby heating
  2. distillationwas distilled off under reduced pressure

出典と根拠

ORDレコード
ord-76bb08361f414ae1bac6777ec3398c82
出典データセット
uspto-grants-2013_06
特許番号
US08466089B2

反応ノート

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