Hydrochloric Acid → HCID 67220219、化合物

反応式

[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:9]2[C:10]3[O:11][CH:12]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:13][CH2:14][C:15]=3[C:16]([C:18]([O:20]C)=[O:19])=[CH:17][C:8]=2[N:7]=[C:6]1[CH3:28].[OH-].[Na+].Cl>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:9]2[C:10]3[O:11][CH:12]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:13][CH2:14][C:15]=3[C:16]([C:18]([OH:20])=[O:19])=[CH:17][C:8]=2[N:7]=[C:6]1[CH3:28]

参加物

反応条件

温度: 80 °C

実験手順

A mixture of methyl 1-(2-methoxyethyl)-2-methyl-8-phenyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylate (1.37 g, 3.61 mmol, Step 11), 2 mol/L sodium hydroxide aqueous solution (3.60 mL, 7.21 mmol), and ethanol (20 mL) was stirred at 80° C. for 2 hours. After cooling to room temperature, 2 mol/L hydrochloric acid (3.60 mL, 7.21 mmol) was added, and the formed precipitate was collected by filtration to afford the title compound as a white solid (1.28 g, 96%).