Hydrochloric Acid → 3-Amino-2,4-difluoro-benzylamine
反応式
[N+:1]([C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[C:7]#[N:8])([O-])=O.Cl>[Pd].CO>[NH2:1][C:4]1[C:5]([F:13])=[C:6]([CH:9]=[CH:10][C:11]=1[F:12])[CH2:7][NH2:8]参加物
5
実験手順
A mixture of 3-Nitro-2,4-difluoro-benzonitrile (0.50 g, 2.7 mmol), MeOH (25 ml), 37% HCl (1.5 ml) and Pd/C (200 mg) was stirred for 13 h at rt under a hydrogen atmosphere (3 bar). The catalyst was removed by filtration and the filtrate was concentrated.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-f6575bf7168b45d4b5567619c4764a90
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466186B2
反応ノート
読み込み中…