3-(5-Chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino)-4-trifluoromethyl-benzonitrile → 4-Trifluoromethyl-3-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzylamine
反応式
[Cl:1][C:2]1[C:24]([N:25]2[CH2:30][CH2:29][CH:28]([C:31]([F:34])([F:33])[F:32])[CH2:27][CH2:26]2)=[CH:23][C:5]2[N:6]([CH3:22])[C:7]([NH:9][C:10]3[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=3[C:18]([F:21])([F:20])[F:19])[C:13]#[N:14])=[N:8][C:4]=2[CH:3]=1>[Ni].C1COCC1>[F:20][C:18]([F:19])([F:21])[C:17]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][C:10]=1[NH:9][C:7]1[N:6]([CH3:22])[C:5]2[CH:23]=[C:24]([N:25]3[CH2:30][CH2:29][CH:28]([C:31]([F:33])([F:34])[F:32])[CH2:27][CH2:26]3)[C:2]([Cl:1])=[CH:3][C:4]=2[N:8]=1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
A mixture of 3-(5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino)-4-trifluoromethyl-benzonitrile (1.20 g; 2.39 mmol), Ra—Ni (14 mg; 0.24 mmol) and THF (50 mL) was shaken under H2-atmosphere (5 atm) overnight at rt. The mixture was filtered through celite and the celite pad was washed with THF and EtOAc. Concentration and crystallization from Et2O/PE gave the sub-title compound.