N-(4-chloro-3-fluoro-5-nitrobenzyl)-1-trifluoromethyl-cyclopropanecarboxamide → N-(3-Amino-4-chloro-5-fluoro-benzyl)-1-trifluoromethyl-cyclopropanecarboxamide

HRID 1258744ノート

反応式

HRID 1258744 の反応式
[Cl:1][C:2]1[C:18]([N+:19]([O-])=O)=[CH:17][C:5]([CH2:6][NH:7][C:8]([C:10]2([C:13]([F:16])([F:15])[F:14])[CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[F:22]>[Ni].C1COCC1>[NH2:19][C:18]1[CH:17]=[C:5]([CH:4]=[C:3]([F:22])[C:2]=1[Cl:1])[CH2:6][NH:7][C:8]([C:10]1([C:13]([F:14])([F:15])[F:16])[CH2:11][CH2:12]1)=[O:9]

参加物

4

反応物 1

HCID 67959823N-(4-chloro-3-fluoro-5-nitrobenzyl)-1-trifluoromethyl-cyclopropanecarboxamide

生成物 1

HCID 67975171N-(3-Amino-4-chloro-5-fluoro-benzyl)-1-trifluoromethyl-cyclopropanecarboxamide

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

H2 was passed through a shaken mixture of N-(4-chloro-3-fluoro-5-nitrobenzyl)-1-trifluoromethyl-cyclopropanecarboxamide (980 mg, 2.88 mmol), Ra—Ni (17 mg, 0.29 mmol) and THF (50 mL) at rt for 1.5 h. The mixture was filtered through celite and concentrated.

後処理

  1. filtrationThe mixture was filtered through celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-af6c8d8bf04e4102a44a172d28fcb01b
出典データセット
uspto-grants-2013_06
特許番号
US08466186B2

反応ノート

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