1,1'-Thiocarbonyldiimidazole → N-(3-Isothiocyanato-4-trifluoromethoxy-benzyl)-2,2-dimethyl-propionamide
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[O:16][C:17]([F:20])([F:19])[F:18])[CH2:5][NH:6][C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9].C1N=CN([C:26](N2C=NC=C2)=[S:27])C=1>CC#N>[N:1]([C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[O:16][C:17]([F:18])([F:19])[F:20])[CH2:5][NH:6][C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9])=[C:26]=[S:27]参加物
4
実験手順
A mixture of N-(3-amino-4-trifluoromethoxy-benzyl)-2,2-dimethyl-propionamide (200 mg, 0.69 mmol), TCDI (133 mg, 0.746 mmol) and MeCN (3 mL) was refluxed for 1 h. Concentration and purification by column chromatography gave the sub-title compound.
後処理
- temperaturewas refluxed for 1 h
- concentrationConcentration and purification by column chromatography
出典と根拠
- ORDレコード
- ord-e2acd49c3d0244c697a35e904d473f78
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466186B2
反応ノート
読み込み中…