Dimethylformamide → 2-Bromo-5-iodobenzoyl chloride

HRID 1258849ノート

反応式

HRID 1258849 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:15])=O.CN(C=O)C>ClCCl>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27355722-Bromo-5-iodobenzoic acid

生成物 1

HCID 583408092-Bromo-5-iodobenzoyl chloride収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 2-bromo-5-iodobenzoic acid (25.0 g, 76.48 mmol) in dichloromethane (200 mL) was added oxalylchloride (10.3 mL, 114.74 mmol) at 0° C. followed by DMF (0.9 mL). After complete addition, the reaction mixture was stirred at room temperature for 3 h. Volatiles were evaporated under reduced pressure to furnish 2-bromo-5-iodo-benzoyl chloride (26.4 g). The crude product was used for the next step immediately.

後処理

  1. additionAfter complete addition
  2. customVolatiles were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-8133b0d50063454599956396d7d55dc7
出典データセット
uspto-grants-2013_06
特許番号
US08466114B2

反応ノート

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