N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide → 2-amino-N-(2-hydroxyethyl)benzenesulfonamide
反応式
[OH:1][CH2:2][CH2:3][NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-])=O)(=[O:7])=[O:6]>CO.[Pd]>[NH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[S:5]([NH:4][CH2:3][CH2:2][OH:1])(=[O:7])=[O:6]参加物
4
実験手順
N-(2-Hydroxyethyl)-2-nitrobenzene sulfonamide (1.25 g, 5.08 mmol) was dissolved in methanol (50 ml) and placed under an atmosphere of nitrogen prior to the addition of 10% Pd/C (10 Wt %, 125 mg) in one portion. The reaction was evacuated, placed under an atmosphere of hydrogen (1 bar) and stirred vigorously overnight. The reaction was filtered through celite and the filtrate was concentrated in vacuo to afford the named product (0.88 g, 80%); LCMS Rt=2.05 min, m/z (ES+) 217 (M+H).
後処理
- customThe reaction was evacuated
- filtrationThe reaction was filtered through celite
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-82d6c8e793454617bfba53602c5a6878
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466201B2
反応ノート
読み込み中…