Sodium Hydroxide → 1-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylic acid

HRID 1260085ノート

反応式

HRID 1260085 の反応式
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][CH:9]=[C:8]1[C:18]([O:20]CC)=[O:19].[OH-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][CH:9]=[C:8]1[C:18]([OH:20])=[O:19]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58355456ethyl 1-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylate

生成物 1

HCID 583555721-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylic acid収率 107.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

Ethyl 1-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylate (430 mg) was dissolved in methanol (2 ml), 2M aqueous sodium hydroxide solution (4 ml) was added and the mixture was stirred at 60° C. for 12 hr. The reaction mixture was concentrated under reduced pressure, and the aqueous layer of the mixture was adjusted to pH 3 with 6M hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the object product (420 mg).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-5e5de1e440f4486fb794590639e9f389
出典データセット
uspto-grants-2013_06
特許番号
US08466282B2

反応ノート

読み込み中…