Hydrochloric Acid → Pyridine, 2-(4-aminopyrazol-1-yl)-

HRID 1260333ノート

反応式

HRID 1260333 の反応式
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][N:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:12]=1)(C)(C)C.Cl.[OH-].[Na+]>O1CCOCC1>[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:11]1[CH:12]=[C:8]([NH2:7])[CH:9]=[N:10]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67299900HCID 67299900、化合物

生成物 1

HCID 206681Pyridine, 2-(4-aminopyrazol-1-yl)-収率 96%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of (1-pyridin-2-yl-1H-pyrazol-4-yl)-carbamic acid tert-butyl ester (185 mg, 0.72 mmol) in dioxane (1.85 ml) was treated with 4M HCl in dioxane (1.85 ml) and the resulting suspension was stirred at ambient temperature for 2 hours. The reaction mixture was adjusted to basic pH with sodium hydroxide (20 ml, 0.5M aqueous solution) and extracted with dichloromethane. The combined organic phases were dried and the solvent was evaporated to yield the product as light brown solid (110 mg, 96%) which was used without any further purification. MS: M=161.3 (M+H)+

後処理

  1. extractionextracted with dichloromethane
  2. customThe combined organic phases were dried
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-9fd12c0b204e4bd3b2985134fb0f058c
出典データセット
uspto-grants-2013_06
特許番号
US08470820B2

反応ノート

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