Sodium Hydroxide → 1-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid

HRID 1260965

反応式

HRID 1260965 の反応式
[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][CH:9]([C:12]([O:14]CC)=[O:13])[CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([C:4]([N:6]2[CH2:7][CH2:8][CH:9]([C:12]([OH:14])=[O:13])[CH2:10][CH2:11]2)=[O:5])[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10036613Ethyl 1-(cyclopropylcarbonyl)piperidine-4-carboxylate

生成物 1

HCID 89029151-(Cyclopropylcarbonyl)piperidine-4-carboxylic acid収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the compound (6.3 g) obtained in step 4 in ethanol (30 mL) was added 4N aqueous sodium hydroxide solution (35 mL), and the mixture was stirred at room temperature for 22 hr. The reaction mixture was concentrated under reduced pressure, and made acidic with 6N hydrochloric acid. The resultant product was extracted with ethyl acetate, the organic layer was washed with brine and dried, and the solvent was evaporated under reduced pressure to give 1-(cyclopropylcarbonyl)piperidine-4-carboxylic acid (5.21 g, 95%) as a pale yellow powder.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionThe resultant product was extracted with ethyl acetate
  3. washthe organic layer was washed with brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-6cd70335563140fd9ea2cbe21af12742
出典データセット
uspto-grants-2013_06
特許番号
US08470816B2

関連ノート

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