Tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate → tert-Butyl 3-hydroxyphenethylcarbamate

HRID 1261449ノート

反応式

HRID 1261449 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16]CC2C=CC=CC=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 59596820Tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate

生成物 1

HCID 11031911tert-Butyl 3-hydroxyphenethylcarbamate収率 101.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1 g of Pd/C 10% was added to a solution of 13 g (0.039 mol) of [2-(3-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester in 100 ml of ethanol. The mixture was hydrogenated at 40 psi overnight. The catalyst was filtered off and washed with ethanol. The solvent was removed under vacuum and 9.4 g of the title compound were obtained as a colourless oil in quantitative yield.

後処理

  1. customwas hydrogenated at 40 psi overnight
  2. filtrationThe catalyst was filtered off
  3. washwashed with ethanol
  4. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-628217ece8404e0c861b619fde3db365
出典データセット
uspto-grants-2013_06
特許番号
US08470877B2

反応ノート

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