Cyclopentanone → 1-(propan-2-yl)cyclopentanol

HRID 1261559ノート

反応式

HRID 1261559 の反応式
[CH:1]([Mg]Cl)([CH3:3])[CH3:2].[C:6]1(=[O:11])[CH2:10][CH2:9][CH2:8][CH2:7]1>>[CH:1]([C:6]1([OH:11])[CH2:10][CH2:9][CH2:8][CH2:7]1)([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 8452CyclopentanoneHCID 178418918HCID 178418918、化合物

生成物 1

HCID 2440031-(propan-2-yl)cyclopentanol

実験手順

According to Example 2, i-PrMgCl (3.30 mL; 3.30 mmol; 1.10 equiv) was reacted with cyclopentanone (252 mg; 3.00 mmol) in the presence of LaCl3.2LiCl (0.33 M; 9.09 mL, 3.00 mmol, 1.00 equiv), the conversion was complete after 5 min (GC monitoring). After workup and careful evaporation of the solvents under reduced pressure, the desired product was obtained as colorless oil (353 mg, 92%). The analytical data were found to be in accordance with the literature data.

後処理

  1. customAfter workup and careful evaporation of the solvents under reduced pressure

出典と根拠

ORDレコード
ord-494c364158d64ef2b3bc6bebef270d5e
出典データセット
uspto-grants-2013_06
特許番号
US08470982B2

反応ノート

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