Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

HRID 1261657ノート

反応式

HRID 1261657 の反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 22707864HCID 22707864、化合物

生成物 1

HCID 227078634-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 4-[2-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (200 mg, 0.61 mmol) in methylene chloride (5 mL) was added trifluoroacetic acid (2.5 mL). After being stirred at room temperature for 45 min, the solution was concentrated to give an oil. MS calculated for C12H12F3N: (M+H) 228; found 228.1.

後処理

  1. concentrationthe solution was concentrated
  2. customto give an oil

出典と根拠

ORDレコード
ord-84edca31b72e4d9a928d8b1cd02587ba
出典データセット
uspto-grants-2013_06
特許番号
US08470827B2

反応ノート

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