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N-[2-(2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide → N-[2-(2-Methanesulfinyl-6-methyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[2-(2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide | HCID 66711409 | — |
| 反応物 | N-[2-(6-Methyl-2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide | HCID 66712338 | — |
| 生成物 | N-[2-(2-Methanesulfinyl-6-methyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide | HCID 66711971 | — |
| 生成物 | N-[2-(6-Methyl-2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide | HCID 66712338 | — |
反応手順
N-[2-(2-Methanesulfinyl-6-methyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide was prepared in an analogous fashion to Example 1220 replacing N-[2-(2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide with N-[2-(6-Methyl-2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide to give N-[2-(6-Methyl-2-methylsulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-methanesulfonamide as an orange residue, which was used without further manipulation (0.13 g, 96%). LC/MS (E/I+) 379.05 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08471005B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-6b28a840c96641e3b1c4d55fc931d87a |
| 出典メモ | uspto-grants-2013_06 |