Dichloromethane → HCID 53256969、化合物

反応式

C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.C(Cl)Cl.FC(F)(F)C(O)=O>>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([C:8]2([NH2:7])[CH2:11][CH2:10][CH2:9]2)[CH:17]=[CH:16][CH:15]=1

参加物

反応物 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 53256967Tert-butyl (1-(3-methoxyphenyl)cyclobutyl)carbamate

生成物 1

HCID 53256969HCID 53256969、化合物

実験手順

Into a 1-neck round-bottom flask, [1-(3-Methoxy-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester (4.20 g, 15.1 mmol), Methylene chloride (25 mL, 390 mmol), and Trifluoroacetic Acid (5 mL, 60 mmol) were added. The reaction was stirred at room temperature overnight. The reaction was partitioned with Saturated NaHCO3 and DCM. The organic was separated, washed with Brine and dried over Na2SO4. The solid was filtered and washed with DCM. The solvent was removed under vacuum to give 1-(3-Methoxy-phenyl)-cyclobutylamine as an oil (2.60, 96%).