Gemcadiol → 2,2,9,9-Tetramethyldecane-1,10-diyl dipyridine-3-carboxylate

HRID 1262824ノート

反応式

HRID 1262824 の反応式
Cl.[C:2](Cl)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.[CH3:11][C:12]([CH3:26])([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([CH3:25])([CH3:24])[CH2:22][OH:23])[CH2:13][OH:14]>N1C=CC=CC=1>[C:2]([O:23][CH2:22][C:21]([CH3:25])([CH3:24])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:12]([CH3:26])([CH3:11])[CH2:13][O:14][C:2](=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1

参加物

4

反応物 2

HCID 37147GemcadiolHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

生成物 1

HCID 30696762,2,9,9-Tetramethyldecane-1,10-diyl dipyridine-3-carboxylate収率 65%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

106.2 Grams (0.6 mole) of nicotinoyl chloride hydrochloride in 300 ml of anhydrous pyridine were reacted with 23.0 grams (0.1 mole) of 2,2,9,9-tetramethyl-1,10-decanediol, according to the procedure described in Example 1. 28.8 Grams of product, recrystallized from ethanol, were obtained, having m.p. 68°-69° C. Yield: 65,5% of theoretical.

後処理

  1. custom28.8 Grams of product, recrystallized from ethanol
  2. customwere obtained

出典と根拠

ORDレコード
ord-0883ef58e7dd448d948e7b158bc10500
出典データセット
uspto-grants-1984_06
特許番号
US04454145

反応ノート

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