6-(Chloroacetyl)quinolin-2(1H)-one → 2-Hydroxyquinoline
反応式
ClCC([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH:9]=[CH:8]2)=O>N1C=CC=CC=1>[NH:11]1[C:12]2[C:7](=[CH:6][CH:5]=[CH:14][CH:13]=2)[CH:8]=[CH:9][C:10]1=[O:15]参加物
3
実験手順
60 Grams of 6-(α-chloroacetyl)carbostyril was suspended in 0.5 kg of pyridine and stirred at 80°-90° C. for 2 hours, then the suspension was stirred under ice-cooling for 1 hour. The crystals thus precipitated were collected by filtration and recrystallized from methanol to obtain 70 g of 6-(α-pyridiniumacetyl)carbostyril chloride 1/2-hydrate in the form of colorless needle-like crystals.
後処理
- stirringthe suspension was stirred under ice-
- temperaturecooling for 1 hour
- customThe crystals thus precipitated
- filtrationwere collected by filtration
- customrecrystallized from methanol
出典と根拠
- ORDレコード
- ord-7d39d34f90ed476ab6c5819d1e483c4d
- 出典データセット
- uspto-grants-1984_06
- 特許番号
- US04454130
反応ノート
読み込み中…