Methanethiol → 2-Methylthio-2,4-dimethylpentan-3-one

HRID 1262979

反応式

HRID 1262979 の反応式
CO.[Na].[CH3:4][SH:5].Br[C:7]([CH3:14])([C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[CH3:8]>O>[CH3:4][S:5][C:7]([CH3:14])([C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[CH3:8]

参加物

6

反応物 4

HCID 878MethanethiolHCID 887MethanolHCID 2225752-Bromo-2,4-dimethylpentan-3-oneHCID 5360545Sodium

生成物 1

HCID 132479432-Methylthio-2,4-dimethylpentan-3-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 200 ml. of methanol containing 9.2 g. (0.40 mole) sodium metal was cooled in an ice-bath and saturated with gaseous methyl mercaptan. To this was added 77.2 g. (0.40 mole) of 2-bromo-2,4-dimethylpentan-3-one at room temperature and the resulting mixture stirred for two hours. The reaction mixture was diluted with water, extracted with ethyl ether, the extracts washed with water, brine and dried over anhydrous sodium sulfate. The ether was evaporated and the residue distilled in vacuo to afford 50.4 g. of product, B.P. 76° (20 mm.).

後処理

  1. additionTo this was added 77.2 g
  2. extractionextracted with ethyl ether
  3. washthe extracts washed with water, brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe ether was evaporated
  6. distillationthe residue distilled in vacuo
  7. customto afford 50.4 g

出典と根拠

ORDレコード
ord-7f976be0716b410096afe8648eebb854
出典データセット
uspto-grants-1984_06
特許番号
US04454328

関連ノート

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