m-Chloroperbenzoic acid → 5-(Oxiran-2-yl)pentan-1-ol

HRID 1263273ノート

反応式

HRID 1263273 の反応式
[CH2:1]([OH:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[CH2:7].ClC1C=CC=C(C(OO)=[O:17])C=1>C(Cl)Cl.CCOCC>[O:8]1[CH2:1][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:17]

参加物

5

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 543123Hept-6-en-1-ol

生成物 1

HCID 136166735-(Oxiran-2-yl)pentan-1-ol収率 105%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3 (1.4 g, 12 mmol) and m-chloroperbenzoic acid (2.92 g, 14.4 mmol) in methylene chloride (40 mL) was stirred at room temperature overnight. It was then diluted with ether, washed with saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride, and dried over magnesium sulfate. Removal of the solvent afforded 1.64 g of the crude 6,7-epoxy-1-heptanol (5).

後処理

  1. washwashed with saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride
  2. dry with materialdried over magnesium sulfate
  3. customRemoval of the solvent

出典と根拠

ORDレコード
ord-5c79409ac5024472978391eca0fc0b90
出典データセット
uspto-grants-1984_06
特許番号
US04456613

反応ノート

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