Sulfuric Acid → N-(2-Methyl-3-methoxycarbonylphenyl)thiourea
反応式
[NH2:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].S(=O)(=O)(O)O.[S-:18][C:19]#[N:20].[Na+].C1OCCOCCOCCOCCOC1>ClC1C=CC=CC=1>[CH3:12][C:3]1[C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:9][CH:10]=[CH:11][C:2]=1[NH:1][C:19]([NH2:20])=[S:18]参加物
6
反応条件
- 温度
- 100 °C
実験手順
90.7 g of methyl 3-amino-2-methylbenzoate (0.55 mol) were dissolved in 510 ml of chlorobenzene and, at −5° C., admixed with 14 ml of conc. sulfuric acid and 49 g of sodium thiocyanate (0.6 mol). 2 ml of 15-crown-5 were then added, and the reaction mixture was heated at 100° C. for 13 h. After cooling, the solid was filtered off with.suction, washed with water and dried. Yield: 104.8 g (85%).
後処理
- temperatureAfter cooling
- filtrationthe solid was filtered off with.suction,
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-06b0b366a69140308df118a7f6eb5f76
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06541423B1
反応ノート
読み込み中…