1,2-Dichloroethane → HCID 18616028、化合物

HRID 1263412ノート

反応式

HRID 1263412 の反応式
[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[C:8]([CH3:15])[C:6]=2[N:7]=1.[CH3:16][N:17]1[C:21](O)=[CH:20][CH:19]=[N:18]1.C(#N)C.C(Cl)CCl>CN(C1C=CN=CC=1)C.O.C(N(CC)CC)C>[CH3:1][NH:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([C:12]([O:14][C:21]3[N:17]([CH3:16])[N:18]=[CH:19][CH:20]=3)=[O:13])=[C:8]([CH3:15])[C:6]=2[N:7]=1

参加物

8

反応物 4

HCID 111,2-DichloroethaneHCID 6342AcetonitrileHCID 186160494-Methyl-2-(methylamino)-1,3-benzothiazole-5-carboxylic acidHCID 178481816HCID 178481816、化合物

生成物 1

HCID 18616028HCID 18616028、化合物

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine触媒HCID 962Water溶媒HCID 8471Triethylamine溶媒

実験手順

3.1 g of 2-methylamino-4-methylbenzothiazole-5-carboxylic acid (0.014 mol) and 1.4 g of 1-methyl-5-hydroxypyrazole (0.015 mol) were dissolved in 110 ml of abs. acetonitrile and admixed with 2.67 g of EDC (0.014 mol), 1,2 ml of triethylamine and a catalytic amount of DMAP. After the reaction had ended, the solution was poured into water and the mixture was extracted with ethyl acetate. The organic phase was washed and dried, and the product was then purified by crystallization. Yield: 2.2 g (52%).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic phase was washed
  3. customdried
  4. customthe product was then purified by crystallization

出典と根拠

ORDレコード
ord-293ef6d524064eb3bf4c40e69bbc5979
出典データセット
uspto-grants-2003_04
特許番号
US06541423B1

反応ノート

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