Ammonium formate → thieno[3,4-d]pyrimidin-4(3H)-one

HRID 1264163

反応式

HRID 1264163 の反応式
[CH:1]([NH:3][C:4]1[C:5]([C:9]([O:11]C)=O)=[CH:6][S:7][CH:8]=1)=O.C([O-])=O.[NH4+:16]>O>[N:3]1[C:4]2=[CH:8][S:7][CH:6]=[C:5]2[C:9](=[O:11])[NH:16][CH:1]=1

参加物

4

反応物 2

HCID 2723923Ammonium formateHCID 2777637Methyl 4-formamidothiophene-3-carboxylate

生成物 1

HCID 135778301thieno[3,4-d]pyrimidin-4(3H)-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
140 °C

実験手順

A stirred mixture of methyl 4-formamido-3-thenoate (see below) (3.39 g) and ammonium formate (3.4 g) in formamde (5 ml) was heated at 140° C. for 7 hours. On cooling, the mixture was poured into water, and the mixture filtered to give a solid which was washed with water followed by light petroleum (b.p. 60-80° C.) and air dried to give the title product, m.p. 275-278° C.

後処理

  1. temperatureOn cooling
  2. filtrationthe mixture filtered
  3. customto give a solid which
  4. washwas washed with water
  5. customdried

出典と根拠

ORDレコード
ord-0dc605da002249468b10d7fc22be35ce
出典データセット
uspto-grants-2003_04
特許番号
US06541630B1

関連ノート

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