Hydroxyamine hydrochloride → 2,4-Dichloro-3-cyano-5-fluorobenzoic acid

HRID 1264334ノート

反応式

HRID 1264334 の反応式
Cl.[NH2:2]O.[Cl:4][C:5]1[C:13]([CH:14]=O)=[C:12]([Cl:16])[C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]>C(O)=O>[C:14]([C:13]1[C:5]([Cl:4])=[C:6]([CH:10]=[C:11]([F:17])[C:12]=1[Cl:16])[C:7]([OH:9])=[O:8])#[N:2]

参加物

4

反応物 2

HCID 443297Hydroxyamine hydrochlorideHCID 186187622,4-Dichloro-5-fluoro-3-formylbenzoic acid

生成物 1

HCID 109005412,4-Dichloro-3-cyano-5-fluorobenzoic acid

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

反応条件

温度
102.5 °C

実験手順

162 g of hydroxylamine hydrochloride were introduced into 2000 ml of formic acid (technical-grade, 85% strength). At 95° C., 950 g of 2,4-dichloro-5-fluoro-3-formylbenzoic acid (moistened with sulphuric acid, 42% strength) were introduced. As a result, the mixture foamed briefly and then a clear solution was immediately obtained. The mixture was then stirred for 4 hours at from 100 to 105° C. (reflux).

後処理

  1. customa clear solution was immediately obtained

出典と根拠

ORDレコード
ord-78e5268f92c24d6097bf8321de437c38
出典データセット
uspto-grants-2003_04
特許番号
US06541675B2

反応ノート

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