Hydrochloric Acid → Methyl 4-aminobenzenebutanoate

HRID 1264348

反応式

HRID 1264348 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.Cl.[C:15]([O-])(O)=O.[Na+].C([O-])([O-])=O.[Na+].[Na+]>CO>[CH3:15][O:12][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([NH2:1])=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 270494-(4-Aminophenyl)butanoic acidHCID 516892Sodium Bicarbonate

生成物 1

HCID 88628Methyl 4-aminobenzenebutanoate収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of 4-(4-aminophenyl)-butyric acid (5 g, 27.90 mmol) in MeOH (100 mL) at room temperature was added HCl conc. (37% 15 mL). The resulting mixture was stirred overnight at 50° C. then treated with a saturated aqueous solution NaHCO3 and Na2CO3 solid until pH 9. The solvent was evaporated under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The crude material was purified by flash chromatography using CH2Cl2/MeOH as solvent mixture yielding 40 (4.93 g, 91%) as orange solid.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. extractionthe aqueous phase was extracted several times with CH2Cl2
  3. customThe crude material was purified by flash chromatography

出典と根拠

ORDレコード
ord-07b5adc5be564ca39d7e597a84da7449
出典データセット
uspto-grants-2003_04
特許番号
US06541661B1

関連ノート

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