1,8-Diazabicyclo(5.4.0)undec-7-ene → 7-Chloro-2-(2-furyl)-5-methylthio[1,2,4]triazolo[1,5-c]pyrimidine
反応式
[Cl:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]2[C:10]([C:13]3[O:14][CH:15]=[CH:16][CH:17]=3)=[N:11][N:12]=[C:4]2[CH:3]=1.C1CCN2C(=NCCC2)CC1>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:12]2[N:11]=[C:10]([C:13]3[O:14][CH:15]=[CH:16][CH:17]=3)[N:5]=[C:4]2[CH:3]=1参加物
4
実験手順
Into 8.5 mL of THF, 2.7 g (10 mmol) of Compound B was dissolved, and 1.5 mL (10 mmol) of DBU was added thereto under ice cooling, followed by stirring at room temperature for about 1 hour. During the period, crystals were precipitated from the reaction solution. After completion of the reaction, the precipitated solid was washed with THF to obtain 2.1 g of Compound C as a white solid (yield: 81%).
後処理
- customDuring the period, crystals were precipitated from the reaction solution
- customAfter completion of the reaction
- washthe precipitated solid was washed with THF
出典と根拠
- ORDレコード
- ord-6506748aabe44da5af3a52bdf9c0354b
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06545000B1
反応ノート
読み込み中…