Phenacyl bromide → Methyl 4-(4-phenyl-2-oxazolyl)benzoate

反応式

[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[CH2:14](Br)[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O>>[C:17]1([C:15]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[O:3][CH:14]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

反応物 2

HCID 6259Phenacyl bromide

HCID 596094Methyl 4-carbamoylbenzoate

生成物 1

HCID 18613870Methyl 4-(4-phenyl-2-oxazolyl)benzoate収率 20%

実験手順

In the same manner as in Example 1, methyl 4-carbamoylbenzoate was reacted with phenacyl bromide to obtain methyl 4-(4-phenyl-2-oxazolyl)benzoate. The product was recrystallized from ethanol. Yield: 20%. Pale yellow prisms. Melting Point: 175 to 176° C.

出典と根拠

ORDレコード: ord-bb90dab78c104cc8bb5272aeb4ef0b2f
出典データセット: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06545009B1

反応ノート

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