2-Bromo-1-(3,4-difluorophenyl)ethan-1-one → Methyl 3-[4-(3,4-difluorophenyl)-2-thiazolyl]benzoate
反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])(=[S:3])[NH2:2].[F:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][C:24]=1[F:25])[C:18](=O)[CH2:19]Br>>[F:14][C:15]1[CH:16]=[C:17]([C:18]2[N:2]=[C:1]([C:4]3[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=3)[C:7]([O:9][CH3:10])=[O:8])[S:3][CH:19]=2)[CH:22]=[CH:23][C:24]=1[F:25]参加物
3
実験手順
In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 3,4-difluorophenacyl bromide to obtain-methyl 3-[4-(3,4-difluorophenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 70%. Colorless prisms. Melting point: 147 to 148° C.
出典と根拠
- ORDレコード
- ord-af57159da4904095a7696de820981d73
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06545009B1
反応ノート
読み込み中…