Nitric Acid → 6-Chloro-2,4-dihydroxy-5-methyl-3-nitropyridine
反応式
Cl.[Cl:2][C:3]1[NH:8][C:7](=[O:9])[CH:6]=[C:5]([OH:10])[C:4]=1[CH3:11].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[Cl:2][C:3]1[NH:8][C:7](=[O:9])[C:6]([N+:12]([O-:14])=[O:13])=[C:5]([OH:10])[C:4]=1[CH3:11]参加物
4
実験手順
6-Chloro-4-hydroxy-5-methyl-1H-pyridin-2-one hydrochloride (64 g) was dissolved in sulfuric acid (325 mL) while cooling in an ice bath. Nitric acid was added drop wise over a period of 90 minutes. The reaction mixture was allowed to stir for an additional 30 minutes and then it was poured into ice water (2 L). The resulting precipitate was isolated by filtration, washed with water and then dried to provide 42.5 g of 6-chloro-4-hydroxy-5-methyl-3-nitro-1H-pyridin-2-one as a light yellow solid.
後処理
- temperaturewhile cooling in an ice bath
- customThe resulting precipitate was isolated by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-07aee488e7514853a571ed8c90eae698
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06545017B1
反応ノート
読み込み中…