6-fluoro-4-oxo-4H-chromene-2-carboxylic acid → 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([C:11]([OH:13])=[O:12])=[CH:8][C:7](=O)[C:6]=2[CH:15]=1.[H][H]>[Pd].C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH:9]([C:11]([OH:13])=[O:12])[CH2:8][CH2:7][C:6]=2[CH:15]=1参加物
5
実験手順
A mixture of 63.4 parts of 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid and 400 parts of acetic acid was hydrogenated at normal pressure and at room temperature with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was stirred in petroleumether. The product was filtered off and dried in vacuo at 70° C., yielding 49 parts (83%) of 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (int. 1).
後処理
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated
- filtrationThe product was filtered off
- customdried in vacuo at 70° C.
出典と根拠
- ORDレコード
- ord-ad9707ec2bf94e2b801764bc2cc1c110
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06545040B1
反応ノート
読み込み中…