Trifluoroacetic acid → HCID 86586796、化合物

反応式

[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([NH:14][NH:15]OC(C)(C)C)=[S:11]=C=O)[CH:5]=1.C1(OC)C=CC=CC=1.[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>>[F:33][C:32]([F:35])([F:34])[C:30]([OH:36])=[O:31].[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([NH:14][NH2:15])=[S:11])[CH:5]=1

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 86586798HCID 86586798、化合物

生成物 1

HCID 86586796HCID 86586796、化合物

実験手順

A solution of 3-(N′-tert-butoxy-carbonyl-hydrazinocarbothioyl)-benzoic acid methyl ester (0.93 g) in TFA (9 mL)/anisole (2 mL) was stirred at 0° C. for 1 h. The solvents were evaporated in vacuum to give crude 3-hydrazinothiocarbonyl-benzoic acid methyl ester trifluoroacetate (0.98 g) as a crystallizing oil.