Thioacetamide → 3-(2,5-Dimethyl-thiazol-4-yl)-benzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=O)[CH:11](Br)[CH3:12])[CH:5]=1.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:19]=[C:16]([CH3:17])[S:18][C:11]=2[CH3:12])[CH:5]=1参加物
3
反応条件
- 温度
- 130 °C
実験手順
A mixture of rac-3-(2-bromo-propionyl)-benzoic acid methyl ester (6.78 g) and thioacetamide (5.63 g) was heated to 130° C. for 20 min. The mixture was partitioned between AcOEt and H2O, the organic layer was dried and evaporated and the residual oil was chromatographed on silica gel using AcOEt/hexane (1:4) as eluent to give 3-(2,5-dimethyl-thiazol-4-yl)-benzoic acid methyl ester (4.97 g) as yellow oil.
後処理
- customThe mixture was partitioned between AcOEt and H2O
- customthe organic layer was dried
- customevaporated
- customthe residual oil was chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-7c1dc49f9b404ab3a95a60a2efe053ca
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06544985B2
反応ノート
読み込み中…