N-bromobutanimide → 3-(5-Bromomethyl-thiazol-4-yl)-benzoic acid methyl ester

HRID 1265634ノート

反応式

HRID 1265634 の反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][C:14]=2[CH3:15])[CH:5]=1.[Br:17]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][S:13][C:14]=2[CH2:15][Br:17])[CH:5]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 696892723-(5-Methyl-thiazol-4-yl)-benzoic acid methyl ester

生成物 1

HCID 696877023-(5-Bromomethyl-thiazol-4-yl)-benzoic acid methyl ester収率 104.6%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of 3-(5-methyl-thiazol-4-yl)-benzoic acid methyl ester (2.40 g), N-bromosuccinimid (2.01 g) and α,α′-bis(isobutyronitrile) (0.02 g) in CCl4 (40 mL) was heated at reflux for 30 min. The cooled mixture was filtered and the solvent was evaporated to give crude 3-(5-bromomethyl-thiazol-4-yl)-benzoic acid methyl ester (3.36 g) as an oil.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 30 min
  3. filtrationThe cooled mixture was filtered
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c17ef2d957ae41fcace9579ab5b3c222
出典データセット
uspto-grants-2003_04
特許番号
US06544985B2

反応ノート

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