Trifluoroacetic acid → 4-(7-Fluoro-4-oxo-8-pyrrolidin-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-pyridine-2-carbonitrile

HRID 1265799ノート

反応式

HRID 1265799 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]([F:19])=[CH:10][C:9]=1[NH:20][C:21](=[O:33])[CH2:22][C:23]([C:25]1[CH:30]=[CH:29][N:28]=[C:27]([C:31]#[N:32])[CH:26]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:19][C:11]1[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:13][C:8]2[N:7]=[C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([C:31]#[N:32])[CH:26]=3)[CH2:22][C:21](=[O:33])[NH:20][C:9]=2[CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86586839{2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-fluoro-5-pyrrolidin-1-yl-phenyl}-carbamic acid tert.-butyl ester

生成物 1

HCID 186134814-(7-Fluoro-4-oxo-8-pyrrolidin-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-pyridine-2-carbonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared from {2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-fluoro-5-pyrrolidin-1-yl-phenyl}-carbamic acid tert.-butyl ester (Example M47) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an orange solid (54 mg).

出典と根拠

ORDレコード
ord-40ec3743141042fc859849a8d523fcec
出典データセット
uspto-grants-2003_04
特許番号
US06544985B2

反応ノート

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