Sodium Hydroxide → N,N-bis(2,3-epoxypropyl)glycine

HRID 1266ノート

反応式

HRID 1266 の反応式
Cl[CH2:2][CH:3]([OH:15])[CH2:4][N:5]([CH2:10][CH:11]([OH:14])[CH2:12]Cl)[CH2:6][C:7]([OH:9])=[O:8].[Na].[OH-].[Na+]>O>[O:14]1[CH2:12][CH:11]1[CH2:10][N:5]([CH2:4][CH:3]1[O:15][CH2:2]1)[CH2:6][C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86752178sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine

生成物 1

HCID 19695060N,N-bis(2,3-epoxypropyl)glycine収率 84%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A reactor was charged with 20 g (0.07 mole) of sodium N,N-bis(3-chloro-2-hydroxypropyl)glycine obtained in the same manner as in Referential Example 1 and 100 g of water, and the contents were kept at 50° C., to which 35 ml of a 4N aqueous solution of sodium hydroxide were added. After the mixture was stirred for 30 minutes, the solvent was distilled off under reduced pressure, and 100 ml of ethanol were added to the residue to separate insoluble matter by filtration. Thereafter, ethanol was distilled off under reduced pressure, thereby obtaining 11 g (isolation yield: 84%) of N,N-bis(2,3-epoxypropyl)glycine.

後処理

  1. additionwere added
  2. distillationthe solvent was distilled off under reduced pressure, and 100 ml of ethanol
  3. additionwere added to the residue
  4. customto separate insoluble matter
  5. filtrationby filtration
  6. distillationThereafter, ethanol was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-f88ac48b7e45476aa2b72c1493bc7762
出典データセット
uspto-grants-1998_03
特許番号
US05723655

反応ノート

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