HCID 575505、化合物 → 2-amino-N-(naphthalen-1-yl)benzamide

HRID 1266471ノート

反応式

HRID 1266471 の反応式
[C:1]1([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N+:20]([O-])=O)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[NH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:12]([NH:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:13]

参加物

4

反応物 1

HCID 575505HCID 575505、化合物

生成物 1

HCID 8519642-amino-N-(naphthalen-1-yl)benzamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of N-naphthyl(2-nitrophenyl)carboxamide in ethanol was added Pd/C and the mixture was stirred under an atmosphere of hydrogen for 16 hours. Pd/C was removed by filtration and the solvent was evaporated. The resulting oil was dissolved in ethyl acetate and extracted with aqueous HCl. The aqueous layer was neutralized and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated to give (2-aminophenyl)-N-naphthylcarboxamide, a compound of Formula I.

後処理

  1. customPd/C was removed by filtration
  2. customthe solvent was evaporated
  3. dissolutionThe resulting oil was dissolved in ethyl acetate
  4. extractionextracted with aqueous HCl
  5. extractionextracted with ethyl acetate
  6. customThe organic layer was separated
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-54040c84f58447f29b1c1e928de9a38a
出典データセット
uspto-grants-2003_04
特許番号
US06548548B2

反応ノート

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