Hydrochloric Acid → Tert-butyl 3-(4-bromophenyl)-2,2-dimethylpropionate

HRID 1266500ノート

反応式

HRID 1266500 の反応式
C([N-]C(C)C)(C)C.[Li+].[CH3:9][CH:10]([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12].[Br:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24]Br)=[CH:22][CH:21]=1.Cl>O1CCCC1>[Br:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][C:10]([CH3:18])([CH3:9])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[CH:22][CH:21]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 685274-Bromobenzyl bromideHCID 519334Tert-butyl 2-methylpropanoateHCID 2724682Lithium diisopropylamide

生成物 1

HCID 22708227Tert-butyl 3-(4-bromophenyl)-2,2-dimethylpropionate収率 85%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-78 °C

実験手順

At −78° C., 34.7 ml (69.4 mmol) of a 2 M lithium diisopropylamide solution are slowly added dropwise to a solution of 10.0 g (69.34 mmol) of tert-butyl 2-methylpropionate (Example I-1) in 100 ml of tetrahydrofuran. After the addition has ended, the mixture is stirred at −78° C. for 1 h, and a solution of 15.76 g (63.04 mmol) of 4-bromobenzyl bromide in 10 ml of tetrahydrofuran is then added and the mixture is stirred at −78° C. for 1 h. The reaction is then warmed to room temperature and poured into 100 ml of 1 N hydrochloric acid, the phases are separated and the aqueous phase is extracted 3× with diethyl ether. The combined organic phases are washed with NaHCO3 solution, dried over sodium sulphate and freed from the solvent under reduced pressure. Distillative purification of the residue under oil pump vacuum gives 16.75 g (85%) of tert-butyl 3-(4-bromophenyl)-2,2-dimethylpropionate.

後処理

  1. customAt −78° C.
  2. additionAfter the addition
  3. stirringthe mixture is stirred at −78° C. for 1 h
  4. temperatureThe reaction is then warmed to room temperature
  5. customthe phases are separated
  6. extractionthe aqueous phase is extracted 3× with diethyl ether
  7. washThe combined organic phases are washed with NaHCO3 solution
  8. dry with materialdried over sodium sulphate
  9. distillationDistillative purification of the residue under oil pump vacuum

出典と根拠

ORDレコード
ord-c1e729df75fb4184a9790a9764544f2f
出典データセット
uspto-grants-2003_04
特許番号
US06548538B2

反応ノート

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