HCID 69780447、化合物 → HCID 86587005、化合物

HRID 1266848ノート

反応式

HRID 1266848 の反応式
C(O[C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5])C>NCCO>[OH:5][CH2:4][CH2:6][NH:7][C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5]

参加物

3

反応物 1

HCID 69780447HCID 69780447、化合物

生成物 1

HCID 86587005HCID 86587005、化合物収率 110.5%

試薬・触媒・溶媒 1

HCID 700Ethanolamine溶媒

実験手順

A solution of 5-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid ethyl ester (Example 23) (35mg) in 2-amino-ethanol (1 mL) was stirred at 50° C. for 4 h. The mixture was partitioned between H2O and EtOAc. The organic layer was dried and evaporated in vacuum, and the residue was triturated with EtOAc to give the title compound (20 mg) as light-yellow solid.

後処理

  1. customThe mixture was partitioned between H2O and EtOAc
  2. customThe organic layer was dried
  3. customevaporated in vacuum
  4. customthe residue was triturated with EtOAc

出典と根拠

ORDレコード
ord-4d3393e9a666440b84cd00455139561c
出典データセット
uspto-grants-2003_04
特許番号
US06548495B2

反応ノート

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