Trifluoroacetic acid → HCID 69779806、化合物

反応式

C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][CH:16]=[CH:15]2)=[CH:10][C:9]=1[NH2:19])(C)(C)C.[CH3:21][O:22][C:23]([C:25]1[N:26]=[C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([C:36]3OC(C)(C)O[C:40](=[O:42])[CH:41]=3)[CH:31]=2)[O:28][CH:29]=1)=[O:24].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:21][O:22][C:23]([C:25]1[N:26]=[C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([C:36]3[CH2:41][C:40](=[O:42])[NH:19][C:9]4[CH:10]=[C:11]([N:14]5[CH:18]=[CH:17][CH:16]=[CH:15]5)[CH:12]=[CH:13][C:8]=4[N:7]=3)[CH:31]=2)[O:28][CH:29]=1)=[O:24]

参加物

実験手順

The title compound was prepared from (2-amino-4-pyrrol-1-yl-phenyl)-carbamic acid tert.-butyl ester (Example J2) (680 mg) and 2-[3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-phenyl]-oxazole-4-carboxylic acid methyl ester (Example L7) (820 mg) according to the general procedure M. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (770 mg).