HCID 69779806、化合物 → HCID 70013376、化合物
反応式
CO[C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:31]=[CH:30][CH:29]=[CH:28]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4]>NCCO>[OH:4][CH2:3][CH2:5][NH:6][C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:31]=[CH:30][CH:29]=[CH:28]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4]参加物
3
実験手順
A solution of 2-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid methyl ester (Example 25) (88 mg) in 2-amino-ethanol (2 mL) was stirred at 50° C. for 2 h. The mixture was partitioned between EtOAc and H2O, the organic layer was dried and evaporated in vacuum. The residue was chromatographed on silicag gel using EtOAc/hexane (1:1) as eluent and the purified product was triturated with Et2O to give the title compound (20 mg) as light-yellow solid.
後処理
- customThe mixture was partitioned between EtOAc and H2O
- customthe organic layer was dried