Hydrazine hydrate (1:1) → 2-Hydrazino-6-(4-trifluoromethylphenoxy)pyridine

HRID 1266922

反応式

HRID 1266922 の反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.O.[NH2:20][NH2:21]>C(O)C>[NH:20]([C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1)[NH2:21]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 185447832-Fluoro-6-(4-trifluoromethylphenoxy)pyridine

生成物 1

HCID 185447862-Hydrazino-6-(4-trifluoromethylphenoxy)pyridine収率 47.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

Next, a reaction flask was loaded with 2-fluoro-6-(4-trifluoromethylphenoxy)pyridine (8.0 g) and ethanol (60 ml), and heated up to 40° C. with stirring. To this mixture, hydrazine monohydrate (7.6 g) was dropwise added in 30 minutes. The temperature of the mixture was raised to the reflux temperature, followed by stirring for 20 hours. Thereafter, the heating was stopped, and the reaction mixture was cooled, followed by filtration to remove insoluble components. The filtrate was condensed by an evaporator to give 2-hydrazino-6-(4-trifluoromethylphenoxy)pyridine (4.0 g).

後処理

  1. temperatureThe temperature of the mixture was raised to the reflux temperature
  2. stirringby stirring for 20 hours
  3. temperaturethe reaction mixture was cooled
  4. filtrationfollowed by filtration
  5. customto remove insoluble components
  6. customcondensed
  7. customby an evaporator

出典と根拠

ORDレコード
ord-172563bbfa8c4f0e8db9a9212f308f10
出典データセット
uspto-grants-2003_04
特許番号
US06551682B1

関連ノート

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