2-Iodo-3-nitrobenzoic acid → 3-Nitrobenzoic acid

反応式

NC1C=CC=C2C=1N(C)N=C2.I[C:13]1[C:21]([N+:22]([O-:24])=[O:23])=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]>>[N+:22]([C:21]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15]([OH:17])=[O:16])([O-:24])=[O:23]

参加物

反応物 2

HCID 2209662-Iodo-3-nitrobenzoic acid

HCID 185454421-methyl-1H-indazol-7-amine

生成物 1

HCID 84973-Nitrobenzoic acid収率 33%

実験手順

Reaction of 7-amino-1-methylindazole and 2-iodo-3-nitrobenzoic acid as above gave 2-8 (1-methyl-1H-indazol-7-yl)amino]-3-nitrobenzoic acid (33% yield); mp (EtOAc/n-hexane) 240-244° C.; 1H NMR [(CD3)2SO] δ 4.33 (s, 3 H, NCH3), 6.55 (d, J=7.5 Hz, 1 H, ArH), 6.84 (t, J=7.7 Hz, 1 H, ArH), 6.90 (t, J=7.7 Hz, 1 H, ArH), 7.36 (d, J=7.9 Hz, 1 H, ArH), 7.80 (dd, J=8.1, 1.7 Hz, 1 H, ArH), 8.00 (s, 1 H, ArH), 8.31 (dd, J=7.5, 1.7 Hz, 1 H, ArH), 13.47 (br s, 1 H, COOH).

出典と根拠

ORDレコード: ord-7daf881a0bcb499e9a31196a483140e7
出典データセット: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06552021B2

反応ノート

読み込み中…

参加物