Sodium Hydroxide → HCID 18545471、化合物
反応式
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]#[N:10].[OH-:14].[Na+]>CCO.O>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[C:9]([NH2:10])=[O:14]参加物
5
実験手順
To a solution of 3-(1,3-dioxolan-2-yl)-benzonitrile (5.86 g) in a mixture of EtOH (140 mL) and H2O (60 mL) was added sodium hydroxide (6.46 g) and the mixture was heated under reflux for 2 hours. The solvent was evaporated under reduced pressure and the aqueous layer was extracted with CH2Cl2. The organic phase was washed with water, dried over Na2SO4, filtered and evaporated to give the title compound (4.5 g) as a white solid.
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 2 hours
- customThe solvent was evaporated under reduced pressure
- extractionthe aqueous layer was extracted with CH2Cl2
- washThe organic phase was washed with water
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-1dd95b2653a142499e029795bfe62634
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06552022B1
反応ノート
読み込み中…