Hydrochloric Acid → HCID 6813148、化合物
反応式
CC([O-])(C)C.[K+].C([O:12][N:13]=O)CC(C)C.[CH2:15]1[CH2:25][C:23](=[O:24])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16]1.Cl>C1COCC1>[C:23]1(=[O:24])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][C:25]1=[N:13][OH:12]参加物
6
実験手順
To the mixture of t-BuOK (1.2 eq.) in THF at 0° C. was added a solution of isoamylnitrite (1.2 eq.) and α-tetralone (Aldrich) (1.0 eq.) in THF dropwise. The reaction mixture was warmed to RT and stirred at RT for 2 h. The reaction mixture was stripped to dryness, mixed with ice-cooled HCl (1M), extracted with EtOAc, washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified with flash chromatography (silica gel, 2:1 hexane/EtOAc) to give the title compound.
後処理
- additionmixed with ice-
- extractionextracted with EtOAc
- washwashed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
- customThe residue was purified with flash chromatography (silica gel, 2:1 hexane/EtOAc)
出典と根拠
- ORDレコード
- ord-8e75cb05bac7445382e32cdabd17b262
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06552013B1
反応ノート
読み込み中…